Uricosuric activity of <i>Tinospora cordifolia</i>
نویسندگان
چکیده
منابع مشابه
Pharmacology of uricosuric drugs.
When the level of uric acid, primarily in the form of monosodium urate (Wilcox, Khalaf, Weinberger, Kippen, and Klinenberg, 1972), exceeds the point of maximum solubility, crystals of monosodium urate may then form, particularly in the joints and connective tissues. These crystals initiate attacks of acute gout (Buchanan, Klinenberg, and Seegmiller, 1965; Seegmiller, 1965; Weissmann, 1971), and...
متن کاملUricosuric targets of tranilast
Uric acid, generated from the metabolism of purines, has both proven and emerging roles in human disease. Serum uric acid in humans is determined by production and by the net balance of reabsorption and secretion in kidney and intestine. In the human kidney, epithelial reabsorption dominates over secretion, such that in normal subjects there is at least 90% net reabsorption of filtered urate re...
متن کاملEvaluation of uricosuric agents in chronic gout.
Experience gained during the past 7 years with the prolonged administration of probenecid (Pascale, Dubin, and Hoffman, 1952; Talbott, 1953; Gutman and Yu, 1955; Bartels, 1955; Bauer and Singh, 1957) or of salicylates (Marson, 1953, 1954, 1955) has shown that continuous therapy with a uricosuric agent in effective doses, is the only practical method at present available for preventing the compl...
متن کاملOrigins of the uricosuric response.
The acute effects of intravenous (i.v.) probenecid and chlorothiazide on renal urate handling were investigated in paired studies in normal men. Uricosuric responses to these agents were compared in the same subjects, both without and with pyrazinamide (PZA) pretreatment. Assuming that PZA selectively inhibits the tubular secretion of urate and that uricosuric agents act by increasing the excre...
متن کاملUricosuric agents in the treatment of gout.
Kersley, Cook, and Tovey (1958) reported the therapeutic value of G.28 315 (sulphinpyrazone), a phenylbutazone derivative now known as Anturan (Geigy), in a group of fifteen patients with gout in a clinical trial lasting 3 to 8 months. Benemid and Longacid (Urelim), a benemid-like drug (Ward, Blenkinsop and Co.), were also given in selected cases. The results, as shown by estimations of the uri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bangladesh Journal of Pharmacology
سال: 2015
ISSN: 1991-0088
DOI: 10.3329/bjp.v10i4.25160